Standard vs Intensive Monitoring Post-Myocardial Infarction Looking for New-Onset Atrial Fibrillation (SIMPL-AF) and Predictors of Poor Outcomes (SIMPL-PPO)

After a myocardial infarction (MI), patients discharged home in sinus rhythm may develop atrial fibrillation (AF) that is asymptomatic, undetected, and under-treated (hereby called “AF post-MI”). By using a non-invasive but intensive monitoring strategy (30-day external cardiac monitor), we hypothesize that AF post-MI will be detected more frequently compared to standard care.

By identifying new-onset AF post-MI, intensive monitoring will likely result in higher rates of oral anticoagulation (OAC) prescription compared to standard care. AF post-MI may also be a  novel predictor of re-hospitalization post-MI, and may be a target for early intervention to prevent re-hospitalization and subsequent adverse outcomes.